Change from propylthiouracil to carbimazole proves fatal.
نویسندگان
چکیده
Recent changes in New Zealand have altered the availability of propylthiouracil. It is no longer a ‘funded’ medication but is only available via an ‘Exceptional Circumstances’ application to the Pharmaceutical Management Agency (PHARMAC). Because of this a number of patients in our practice were changed from propylthiouracil to carbimazole. We report a patient who developed agranulocytosis following this change in medication which led to her death from Aspergillus pneumonia.
منابع مشابه
Suspected Spontaneous Reports of Birth Defects in the UK Associated with the Use of Carbimazole and Propylthiouracil in Pregnancy
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BACKGROUND ANCA is detected in several vasculitic diseases, including drug-induced systemic vasculitis: propylthiouracil (PTU), hydralazine, minocycline, penicillamine, allopurinol, procainamide, carbimazole, thiamazole, clozapine and phenytoin. All have been known to induce ANCA positive vasculitis in adult patients. OBJECTIVE To study the clinical manifestation, renal pathology and outcome ...
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ورودعنوان ژورنال:
- The New Zealand medical journal
دوره 114 1145 شماره
صفحات -
تاریخ انتشار 2001